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In the original 2015 Cell Metabolism paper, MOTS-c activated AMPK, improved insulin sensitivity in diet-induced obese mice, and reduced age-related insulin resistance in older animals [2]
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Tirzepatide has a longer escalation period (20 weeks to maximum versus 16 weeks for semaglutide), which means the GI adjustment period extends over more time but may be less intense at each step
As an additional example to that of the trefoil peptides noted above, the peptide EGF (epidermal growth factor) is produced in human milk to promote growth of the gastrointestinal tract in newborn infants, but the same peptide aggressively stimulates the growth of breast cancer cells in adults
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